Neutrophils produce biologically active macrophage inflammatory protein-3α (MIP-3α) / CCL20 and MIP-3β / CCL19
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منابع مشابه
Localization of Distinct Peyer's Patch Dendritic Cell Subsets and Their Recruitment by Chemokines Macrophage Inflammatory Protein (Mip)-3α, Mip-3β, and Secondary Lymphoid Organ Chemokine
We describe the anatomical localization of three distinct dendritic cell (DC) subsets in the murine Peyer's patch (PP) and explore the role of chemokines in their recruitment. By two-color in situ immunofluorescence, CD11b(+) myeloid DCs were determined to be present in the subepithelial dome (SED) region, whereas CD8alpha(+) lymphoid DCs are present in the T cell-rich interfollicular region (I...
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In this study, mRNA expression for novel T-lymphocyte chemoattractants, Leukotactin-1, Macrophage inflammatory protein (MIP)-3α and MIP-3β, was investigated in bronchoalveolar lavage fluid (BALF) cells from patients with sarcoidosis, a T-cell-mediated disease with typical CD4+ lymphocyte alveolitis. Of these three chemokines, only MIP-3β mRNA was upregulated in sarcoidosis and, therefore, prote...
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Background and aim: Macrophage inflammatory protein 3α (MIP-3α) is a recently described lymphocyte directed C-C chemokine expressed predominately at extralymphoid sites, including the intestine. The aim of this study was to determine whether colonic epithelial cells produce MIP-3α and whether its expression is upregulated in inflammatory bowel disease. Methods and results: We found that interle...
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BACKGROUND The first identified susceptibility gene for Crohn's disease, NOD2, acts as a sensor for the bacterial-wall peptidoglycan fragment muramyl dipeptide (MDP) and activates the transcription factor nuclear factor-κB (NF-κB). Upon NF-κB activation, intestinal macrophages (IMACs) induce expression of macrophage inflammatory protein (MIP)-3α to attract memory T lymphocytes. We therefore inv...
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BACKGROUND : Accumulation of T cells and immature dendritic cells (DCs) is one of the characteristic features of nasal polyps. However, the question remains why these cells accumulate in nasal polyp tissue. Macrophage inflammatory protein-3α; (MIP-3α;/CCL20) is a chemokine involved in the migration of T cells and immature DCs into inflammatory tissue sites. Fibroblasts are a rich source of cyto...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2001
ISSN: 0014-2980,1521-4141
DOI: 10.1002/1521-4141(200107)31:7<1981::aid-immu1981>3.3.co;2-o